1B20.21

ICD-11 MMS 2026-01

Type II leprosy reaction

Description

This phenomenon, also named downgrading reaction, occurs in borderline leprosy states and is associated with a decrease in cell-mediated immunity with a shift towards the lepromatous end of the clinical spectrum.

Index terms

  • Type II leprosy reaction
  • Type II downgrading reaction
  • Erythema nodosum leprosum
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  • Lucio phenomenon

Exclusions from above levels

  • NE83.1 – Infection arising from device, implant or graft, not elsewhere classified

Sibling codes

  • 1B20.20 – Type I leprosy reaction

Foundation entity

Type II leprosy reaction – http://id.who.int/icd/entity/1886317801

Allowed postcoordination axes

Part of: 1B20.2: Leprosy reactions › 1B20: Leprosy › 01: Certain infectious or parasitic diseases