Malignant neoplasms of liver or intrahepatic bile ducts

Description

The most frequent and important hepatic neoplasm is the primary hepatocellular carcinoma (HCC). In many parts of the world, in particular Africa and Asia, it poses a significant disease burden. In these high incidence regions, chronic infection with hepatitis B virus (HBV) is the principal underlying cause, with the exception of Japan which has a high prevalence of hepatitis C infection. HBV vaccination has become a powerful tool in reducing cirrhosis and HCC, but implementation is still suboptimal in several high risk regions. In Western countries, chronic alcohol abuse is a major aetiological factor. Hepatic cholangiocarcinoma has a different geographical distribution, with peak incidences in Northern Thailand. Here, it is caused by chronic infection with the liver fluke, Opisthorchis viverrini, which is ingested through infected raw fish.

Coding note from above levels

For use of this category, reference should be made to the mortality coding rules and guidelines in the Reference Guide.

Excludes

• 2C17 – Malignant neoplasm of biliary tract NOS
• 2D80 – Secondary malignant neoplasm of liver

Exclusions from above levels

• http://id.who.int/icd/entity/111033337 – Malignant neoplasm metastasis in digestive system
• http://id.who.int/icd/entity/1965082709 – Malignant mesenchymal neoplasms
• http://id.who.int/icd/entity/794095161 – Malignant neoplasms of lip, oral cavity or pharynx