2C81.0

ICD-11 MMS 2026-01

Squamous cell carcinoma of penis

Description

A squamous cell carcinoma arising from the penis. It occurs chiefly in the squamous epithelium of the glans, coronal sulcus, and foreskin. Etiologic factors include phimosis, lichen sclerosus, smoking, ultraviolet irradiation, history of warts or condylomas, and lack of circumcision. Human papilloma virus is present in a subset of penile squamous cell carcinomas. Patients may present with an exophytic or flat ulcerative mass in the glans or a large primary tumour with inguinal nodal and skin metastases. Morphologic variants include the basaloid carcinoma, warty (condylomatous) carcinoma, verrucous carcinoma, and sarcomatoid (spindle cell) carcinoma.

Coding note from above levels

Includes malignant neoplasm of skin of male genital organs

For use of this category, reference should be made to the mortality coding rules and guidelines in the Reference Guide.

Index terms

  • Squamous cell carcinoma of penis
  • Squamous cell carcinoma of mucocutaneous epithelium of penis
  • Squamous cell carcinoma of skin of penis

Exclusions from above levels

  • 2E06 – Malignant neoplasm metastasis in penis
  • http://id.who.int/icd/entity/1965082709 – Malignant mesenchymal neoplasms
  • http://id.who.int/icd/entity/879154182 – Neoplasms of central nervous system or related structures
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  • http://id.who.int/icd/entity/944754984 – Neoplasms of haematopoietic or lymphoid tissues

Sibling codes

  • 2C81.1 – Melanoma of penis
  • 2C81.Y – Other specified malignant neoplasm of penis
  • 2C81.Z – Malignant neoplasms of penis, unspecified

Foundation entity

Squamous cell carcinoma of penis – http://id.who.int/icd/entity/186592209

Allowed postcoordination axes

Part of: 2C81: Malignant neoplasms of penis › 02: Neoplasms