4A85.04

ICD-11 MMS 2026-01

Multiple drug hypersensitivity syndrome

Description

Multiple drug hypersensitivity syndrome is defined as drug allergies to two or more chemically different drugs. It differs from cross-reactivity (due to structural similarities, common metabolic pathways, or pharmacological mechanisms), flare- up reactions (exacerbation of an existing drug allergy by the early switch of therapy to a novel drug), and multiple drug intolerance syndrome.

Index terms

  • Multiple drug hypersensitivity syndrome

Exclusions from above levels

  • 02 – Neoplasms
  • 18 – Complications of pregnancy, childbirth and the puerperium
  • 20 – Developmental anomalies

Sibling codes

  • 4A85.00 – Drug-induced liver hypersensitivity disease
  • 4A85.01 – Drug-induced kidney hypersensitivity
  • 4A85.02 – Drug-induced cytopenia
  • 4A85.03 – Drug-induced vasculitis
  • 4A85.0Y – Drug hypersensitivity of other specified type
  • 4A85.0Z – Drug hypersensitivity of unspecified type

Foundation entity

Multiple drug hypersensitivity syndrome – http://id.who.int/icd/entity/1936492387

Part of: 4A85.0: Drug or pharmacological agents hypersensitivity › 4A85: Complex allergic or hypersensitivity conditions › 04: Diseases of the immune system