5A70.0

ICD-11 MMS 2026-01

Pituitary-dependent Cushing disease

Description

Pituitary-dependent Cushing disease is caused by a pituitary tumour, generally benign (adenoma) but rarely malignant (carcinoma), which secretes adrenocorticotropin (ACTH) autonomously, leading to hypercortisolism. The condition is associated with increased morbidity and mortality that can be mitigated by treatments that result in sustained endocrine remission. Transsphenoidal pituitary surgery (TSS) remains the mainstay of treatment for this disease but requires considerable neurosurgical expertise and experience in order to optimize patient outcomes.

Index terms

  • Pituitary-dependent Cushing disease
  • ACTH- [adrenocorticotropic hormone] secreting pituitary adenoma
  • Corticotroph pituitary adenoma
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  • Cushing disease
  • Cushing syndrome or disease, pituitary-dependent
  • Cushing's disease
  • Cushing's syndrome 3
  • Cushings basophilism
  • Itsenko disease
  • Itsenko-Cushing syndrome
  • Overproduction of pituitary ACTH
  • Pituitary-dependent hyperadrenocorticism
  • pituitary ACTH hypersecretion
  • pituitary basophilism
  • pituitary-dependent hypercorticalism
  • suprarenogenic syndrome

Exclusions from above levels

  • 18 – Pregnancy, childbirth or the puerperium
  • http://id.who.int/icd/entity/1004987305 – Transitory endocrine or metabolic disorders specific to fetus or newborn

Sibling codes

  • 5A70.1 – Ectopic ACTH syndrome
  • 5A70.2 – Pseudo-Cushing syndrome
  • 5A70.3 – Nelson syndrome
  • 5A70.Y – Other specified Cushing syndrome
  • 5A70.Z – Cushing syndrome, unspecified

Foundation entity

Pituitary-dependent Cushing disease – http://id.who.int/icd/entity/380861892

Part of: 5A70: Cushing syndrome › 05: Endocrine, nutritional or metabolic diseases