6A80.3

ICD-11 MMS 2026-01

Current depressive episode with melancholia

Description

In the context of a current Depressive Episode, several of the following symptoms have been present during the worst period of the current episode: loss of interest or pleasure in most activities that are normally enjoyable to the individual (i.e., pervasive anhedonia); lack of emotional reactivity to normally pleasurable stimuli or circumstances (i.e., mood does not lift even transiently with exposure); terminal insomnia (i.e., waking in the morning two hours or more before the usual time); depressive symptoms are worse in the morning; marked psychomotor retardation or agitation; marked loss of appetite or loss of weight.

Coding note

These categories should never be used in primary coding. The codes are provided for use as supplementary or additional codes when it is desired to identify specific clinically important features of mood episodes in mood disorders.

Index terms

  • Current depressive episode with melancholia

Exclusions from above levels

  • QE62 – Uncomplicated bereavement
  • QE84 – Acute stress reaction

Sibling codes

  • 6A80.0 – Prominent anxiety symptoms in mood episodes
  • 6A80.1 – Panic attacks in mood episodes
  • 6A80.2 – Current depressive episode persistent
  • 6A80.4 – Seasonal pattern of mood episode onset
  • 6A80.5 – Rapid cycling

Foundation entity

Current depressive episode with melancholia – http://id.who.int/icd/entity/802537726

Allowed postcoordination axes

Part of: 6A80: Symptomatic and course presentations for mood episodes in mood disorders › 06: Mental, behavioural or neurodevelopmental disorders