6C4A.4

ICD-11 MMS 2026-01

Nicotine withdrawal

Description

Nicotine withdrawal is a clinically significant cluster of symptoms, behaviours and/or physiological features, varying in degree of severity and duration, that occurs upon cessation or reduction of use of nicotine (typically used as a constituent of tobacco) in individuals who have developed Nicotine dependence or have used nicotine for a prolonged period or in large amounts. Presenting features of Nicotine withdrawal may include dysphoric or depressed mood, insomnia, irritability, anger, anxiety, difficulty concentrating, restlessness, bradycardia, increased appetite, and craving for tobacco (or other nicotine-containing products). Other physical symptoms may include increased cough and mouth ulceration.

Index terms

  • Nicotine withdrawal
  • tobacco withdrawal state

Exclusions from above levels

  • QE62 – Uncomplicated bereavement
  • QE84 – Acute stress reaction

Sibling codes

  • 6C4A.0 – Episode of harmful use of nicotine
  • 6C4A.1 – Harmful pattern of use of nicotine
  • 6C4A.2 – Nicotine dependence
  • 6C4A.3 – Nicotine intoxication
  • 6C4A.Y – Other specified disorders due to use of nicotine
  • 6C4A.Z – Disorders due to use of nicotine, unspecified

Foundation entity

Nicotine withdrawal – http://id.who.int/icd/entity/441538

Allowed postcoordination axes

Part of: 6C4A: Disorders due to use of nicotine › 06: Mental, behavioural or neurodevelopmental disorders