EH65

ICD-11 MMS 2026-01

DRESS syndrome

Description

DRESS syndrome (Drug Rash with Eosinophilia and Systemic Symptoms) is a hypersensitivity reaction characterised by a generalised skin rash, fever, eosinophilia, lymphocytosis and visceral involvement (hepatitis, nephritis, pneumonitis, pericarditis and myocarditis) and, in some patients, reactivation of human herpes virus 6.

Index terms

  • DRESS syndrome
  • DIHS - [drug-induced hypersensitivity syndrome]
  • Drug rash with eosinophilia and systemic symptoms
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  • Drug-induced hypersensitivity syndrome

Inclusions

  • Drug-induced hypersensitivity syndrome

Sibling codes

  • EH60 – Exanthematic drug eruption
  • EH61 – Drug-induced urticaria, angioedema or anaphylaxis
  • EH62 – Lichenoid drug eruption
  • EH63 – Stevens-Johnson syndrome or toxic epidermal necrolysis due to drug
  • EH64 – Drug-induced erythroderma
  • EH66 – Fixed drug eruption
  • EH67 – Acne or acneiform reactions attributable to drugs
  • EH6Y – Drug eruption of other specified type
  • EH6Z – Drug eruption of unspecified type

Foundation entity

DRESS syndrome – http://id.who.int/icd/entity/516577496

Allowed postcoordination axes

Part of: 14: Diseases of the skin