Catalog

Lissencephaly due to TUBA1A gene mutation

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Link to WHO Definition

Lissencephaly due to TUBA1A gene mutation – http://id.who.int/icd/entity/1006889224

Lissencephaly (LIS) due to TUBA1A mutation is a congenital cortical development anomaly due to abnormal neuronal migration involving neocortical and hippocampal lamination, corpus callosum, cerebellum and brainstem. A large clinical spectrum can be observed, from children with severe epilepsy and intellectual and motor deficit to cases with severe cerebral dysgenesis in the antenatal period leading to pregnancy termination due to the severity of the prognosis.