Catalog

Neuromuscular junction disorder due to organophosphate ingestion

No MMS code

Link to WHO Definition

Neuromuscular junction disorder due to organophosphate ingestion – http://id.who.int/icd/entity/1119553440

The late manifestations of organophosphate (OP) and carbamate toxicity include intermediate syndrome (IMS), and OP-induced delayed neuropathy. IMS manifesting with neck muscle weakness, proximal muscle weakness and rarely cranial nerve lesions (extraocular, facial weakness) occurs after recovery from a cholinergic crisis (acute toxicity due to insecticide poisoning). If neck muscle weakness is present or age is >45 years patients are at risk of late respiratory failure. Clinical weakness of IMS is experienced in 20-60%. The neuromuscular weakness can generalize with respiratory failure and a fatal outcome ( 15-65%). If there is no respiratory muscle involvement weakness subsides in 1-7 days.