Catalog

Autoimmune hyperexcitability syndrome with continuous muscle fibre activity or Morvan syndrome

No MMS code

Link to WHO Definition

Autoimmune hyperexcitability syndrome with continuous muscle fibre activity or Morvan syndrome – http://id.who.int/icd/entity/1155795500

The autoimmune hyperexcitability syndrome with continuous muscle fibre activity (CMFA), is a rare neuromuscular syndrome characterised by muscle weakness, often myokymia, CMFA, at times a cramp and fasciculation syndrome and autonomic features. Paraesthesia and hyperhydrosis are also common. Also CNS symptoms can be associated in Morvan`s syndrome. It can appear both as an autoimmune- and a paraneoplastic disease. An association with thymoma exists. The disease is often antibody mediated in particular with potassium channel antibodies (VGKC) and anti-CASPR2. It responds to symptomatic therapy and immune therapies.