Catalog

Paraneoplastic encephalopathy

No MMS code

Link to WHO Definition

Paraneoplastic encephalopathy – http://id.who.int/icd/entity/1385914006

Paraneoplastic encephalopathy results from a targeted attack on the central nervous system as a consequence of a potentially effective tumour immune response initiated by onco-neural antigens derived from a systemic cancer . It is similar to paraneoplastic encephalitis [see paraneoplastic encephalitis definition] but the manifestations are generally less acute and not as severe consisting mainly of memory difficulties, psychiatric symptoms and seizures but basal ganglia and brainstem involvement can also occur. Similar to paraneoplastic encephalitis accompanying paraneoplastic neural autoantibodies may be found [see paraneoplastic encephalitis or encephalopathy: neural autoantibody positive definition] and other investigations show similar results. If neural antibody positive, associated neural autoantibodies include: AMPA-R (amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor antibodies); amphiphysin; ANNA-1[anti-Hu] (antineuronal nuclear autoantibody type 1); ANNA-2(anti-Ri) (antineuronal nuclear autoantibody type 2); ANNA-3 (antineuronal nuclear autoantibody type 3); CRMP5(anti-CV2) (collapsin response mediator protein 5); GABABR (Gamma-aminobutyric-acid antibodies); Ma1; Ma2; mGluR5 (metabotropic glutamate receptor antibody type 5); NMDA-R (N-methyl-D-aspartate receptor autoantibodies); PCA-2 (purkinje cell cytoplasmic autoantibody type 2); PCA-Tr purkinje cell autoantibody-Tr;