Catalog

Diffuse non-epidermolytic palmoplantar keratoderma

No MMS code

Link to WHO Definition

Diffuse non-epidermolytic palmoplantar keratoderma – http://id.who.int/icd/entity/1481454585

Diffuse non-epidermolytic palmoplantar keratoderma (MIM #600962 ) is an autosomal dominant disorder caused by mutations in the keratin 1 gene. It presents in early childhood even, very thick, yellow hyperkeratosis over the whole of the foot and spreading later to the palms. There is a sharp cut-off at the wrist and no tendency to spread to extensor surfaces. Hyperhidrosis is usual and dermatophyte infection is common.