Catalog

Wolfram syndrome

No MMS code

Link to WHO Definition

Wolfram syndrome – http://id.who.int/icd/entity/151381747

Wolfram syndrome, also called DIDMOAD (Diabetes Insipidus, Diabetes Mellitus, Optic Atrophy, and Neural Deafness), is a rare genetic disorder, causing diabetes mellitus, optic atrophy, and neural deafness as well as diabetes insipidus. An autosomal recessive form due to an inactivating mutation in the AVP portion of the gene, an X-liked recessive form due to an unidentified gene on Xq28, and an autosomal recessive form due to mutations of the WFS 1 gene are responsible for Wolfram syndrome.