Catalog

Nephrogenic systemic fibrosis

No MMS code

Link to WHO Definition

Nephrogenic systemic fibrosis – http://id.who.int/icd/entity/1537082562

Nephrogenic systemic fibrosis (NSF) is an iatrogenic systemic fibrosing disorder which affects principally skin and joints and which is due to exposure of patients with moderate to severe kidney failure to gadolinium-containing contrast agents. It manifests with induration, thickening, and hardening of the skin, especially of the extremities, and may be associated with joint contractures. Histopathologically there is a proliferation of dermal fibroblasts and dendritic cells with deposition of collagen and mucin.