Catalog

Autoimmune necrotising myopathy

No MMS code

Link to WHO Definition

Autoimmune necrotising myopathy – http://id.who.int/icd/entity/1655474050

Presents with proximal muscle weakness occurring during or after treatment with statins; often associated with elevated serum creatine kinase (CK). The muscle weakness can persist, after discontinuation of statin treatment. Neuropathologically gives evidence of necrotizing myopathy with scarce inflammation. Immune suppressive therapy may be needed. Associated neural autoantibodies are Anti- SRP (signal recognition particle antibody) and anti HMGCR (Autoantibodies recognizing 3-hydroxy-3-methylglutaryl-coenzyme A reductase)