Catalog

Luft disease

No MMS code

Link to WHO Definition

Luft disease – http://id.who.int/icd/entity/1863060210

Luft’s disease is clinically characterised by hypermetabolism and consequent abnormal transpiration. The hypermetabolism is caused by extensive uncoupling of mitochondrial respiration in skeletal muscle tissue. Muscle mitochondria are structurally modified, with the cristae assuming a zig-zag conformation. This damage is conceived to be caused by a genetic defect preventing proper aggregation of the enzyme molecules in the cristae.