Catalog

Indomethacin embryofetopathy

No MMS code

Link to WHO Definition

Indomethacin embryofetopathy – http://id.who.int/icd/entity/1929563114

fetal indomethacin syndrome is a teratogenic disorder resulting from the maternal exposure to indomethacin, a nonsteroidal anti-inflammatory drug (NSAID), during pregnancy. There is a moderate increase in cardiac defects (especially ventricular or auricular septal defects) in children exposed in utero during the first trimester. Later effects occur in less than 1 in 5,000 treated patients, with impairment of fetal and neonatal renal function. As with other inhibitors of prostaglandin synthetase, there have been reports of premature closure of the ductus arteriosus and subsequent pulmonary hypertension in fetuses between the 27th and the 35th weeks of gestation.