Catalog

Disorders of the neuromuscular junction in botulism

No MMS code

Link to WHO Definition

Disorders of the neuromuscular junction in botulism – http://id.who.int/icd/entity/1964734963

Disorders of neuromuscular junction in botulism are rare diseases caused by exposure to the neurotoxins produced by the anaerobe Clostridium botulinum. The three toxin subtypes A, B and E all act by cleaving a coordinated assembly of proteins, such as syntaxin 1, SNAP 25 and synaptobrevin, that bring the vesicle and the plasma membranes into close apposition, in preparation for exocytosis. Their action prevents the close apposition of vesicles to the presynaptic membrane, leading to a failure of acetylcholine release.