Catalog

Delayed muscle maturation

No MMS code

Link to WHO Definition

Delayed muscle maturation – http://id.who.int/icd/entity/2066173407

Delayed muscle maturation refers to a delay of the finely tuned multi-step process that is initiated by the specification of mesodermal precursors into proliferating myoblasts which undergo cell cycle withdrawal, differentiation and fusion to form multinucleated muscle fibres. This result in an alteration of the fusion of myoblasts into mature multinucleated syncitia, which is a critical component of muscle formation and it is regulated by the tight coordination of actin- and membrane-based dynamics.