Catalog
Langerhans cell histiocytosis
Link to WHO Definition
Langerhans cell histiocytosis – http://id.who.int/icd/entity/216625985
A neoplastic proliferation of Langerhans cells which contain Birbeck granules by ultrastructural examination. Three major overlapping syndromes are recognised: eosinophilic granuloma, Letterer-Siwe disease, and Hand-Schuller-Christian disease. The clinical course is generally related to the number of organs affected at presentation.