Catalog

Polycystic lipomembranous osteodysplasia - sclerosing leukoencephalopathy

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Link to WHO Definition

Polycystic lipomembranous osteodysplasia - sclerosing leukoencephalopathy – http://id.who.int/icd/entity/295989674

Nasu-Hakola disease, also referred to as polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL), is a rare inherited leukodystrophy characterised by progressive presenile dementia associated with recurrent bone fractures due to polycystic osseous lesions of the lower and upper extremities.