Catalog
Persistent hyperinsulinaemic hypoglycaemia of infancy
Link to WHO Definition
Persistent hyperinsulinaemic hypoglycaemia of infancy – http://id.who.int/icd/entity/402589098
Congenital isolated hyperinsulinism, or Persistent hyperinsulinaemic hypoglycaemia of infancy (PHHI) is defined by an inappropriate oversecretion of insulin by the endocrine pancreas that is responsible for profound hypoglycaemia, which requires aggressive medical and/or surgical treatment to prevent severe and irreversible brain damage. PHHI is a genetically heterogeneous disorder with two types of histological lesions: diffuse (DiPHHI) and focal (FoPHHI) which are clinically indistinguishable.