Catalog

Hereditary nonpolyposis colorectal cancer

No MMS code

Link to WHO Definition

Hereditary nonpolyposis colorectal cancer – http://id.who.int/icd/entity/8113015

Lynch syndrome (HNPCC or Hereditary nonpolyposis colorectal cancer) is an autosomal dominant genetic condition which has a high risk of colon cancer as well as other cancers including stomach, small intestine, liver, gallbladder ducts, upper urinary tract, brain, skin, and prostate. Women with this disorder also have a high risk of cancer of the endometrium (lining of the uterus) and ovaries.The increased risk for these cancers is due to inherited mutations that impair DNA mismatch repair.