Catalog

COASY Protein-Associated Neurodegeneration

No MMS code

Link to WHO Definition

COASY Protein-Associated Neurodegeneration – http://id.who.int/icd/entity/849690656

COASY (Coenzyme A Synthase) protein-associated neurodegeneration (CoPAN) is a rare but devastating genetic autosomal recessive disorder of inborn error of CoA (coenzyme A) metabolism, which shares with pantothenate kinase-associated neurodegeneration (PKAN) similar features, such as dystonia, parkinsonian traits, cognitive impairment, axonal neuropathy, and brain iron accumulation. These two disorders are part of the big group of neurodegenerations with brain iron accumulation (NBIA).