Catalog

Paraneoplastic acanthosis nigricans

No MMS code

Link to WHO Definition

Paraneoplastic acanthosis nigricans – http://id.who.int/icd/entity/915843260

Paraneoplastic acanthosis nigricans is thought to be due to production by the associated malignant tumour of factors which stimulate epidermal keratinocyte and dermal fibroblast proliferation. It is most commonly linked to underlying gastro-intestinal malignancy. In a third of cases it precedes the diagnosis of cancer. In contrast with benign acanthosis nigricans it often involves the extremities (tripe palms) and oral cavity.