ERBB2 gene copy number/Chromosome 17 copy number in Tissue by FISH

ERBB2 copy num/Chr 17 copy num Tiss FISH

Definition

The ratio of HER-2/neu (ERBB2 gene) to CEP17 probes by in situ hybridization assays (e.g. FISH) to determine overexpression of HER-2/neu protein in breast cancer. CEP17 is used as an internal control and to account for aneusomy (varying number) of chromosome 17. A ratio of >2.0 indicates gene amplification and overexpression of HER-2/neu according to the 2013 ASCO-CAP HER2 test guideline recommendations. Results are used to assist in dose selection for certain drugs, assess eligibility for trastuzumab (Herceptin®) treatment, predict response to drug therapies and overall survival in patients with breast cancer. For testing without an internal control probe, see LOINCs 31150-6 and 48675-3. For determining HER-2 status by Immunohistochemistry (IHC), see LOINC 18474-7.

breast cancer; CD340; CEP17; c-erb B2; Chr 17 copy num; Chromosom; Chromosome 17 centromere; Chromosome Enumeration Probe 17; Chromosomes; ErbB-2; ERBB2 copy num; erb-b2 receptor tyrosine kinase 2; Fluorescent in situ hybridization; Genetics; HER2; HER-2; HER2/neu; HER-2/neu; Heredity; Heritable; Inherited; MLN 19; Molecular pathology; MOLPATH; NEU; NGL; No; Num; Number ratio; Oncology; p185; Point in time; QNT; Quan; Quant; Quantitative; Random; Tissue; Tissue, unspecified; TKR1; v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog)

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