Glutamate decarboxylase 65 Ab [Moles/volume] in Cerebral spinal fluid

GAD65 Ab CSF-sCnc

Definition

Glutamic acid decarboxylase (GAD65) is an enzyme that is produced primarily by pancreatic islet cells. Glutamic Acid Decarboxylase antibodies are present in the majority of individuals with new-onset diabetes and in individuals in the prediabetic phase of the disease. It appears early in the disease process prior to clinical symptoms and can be used to predict who will develop IDDM (insulin-dependent diabetes mellitus). Measurement of GAD65 antibody can be of use in distinguishing insulin-dependent from non-insulin dependent diabetics when the clinical history is ambiguous. GAD65 autoantibodies are often markedly elevated in patients with the stiff-person syndrome (also known as stiff-man syndrome), a condition that is associated with fluctuating stiffness and paroxysmal spasms of the trunk and legs. Information from http:www.labcorp.com (Laboratory Corporation of America), accessed 2008 02 13.

ABS; Aby; Antby; Anti; Antibodies; Antibody; Autoantibodies; Autoantibody; Autoimmune myelopathy; c707; Cerebral spinal fluid; Cerebrospinal Fl; GAD; GAD65; GAD-65; GADA; Glu; Glutamic acid; Glutamic acid decarboxylase-65; Insulin-Dependent Diabetes Mellitus; Level; Neuro; Neurology; Paraneoplastic neurological syndrome; Point in time; QNT; Quan; Quant; Quantitative; Random; Serology; Spinal Fl; Spinal Fld; Spinal Flu; Spinal Fluid; Substance concentration