Neuronal nuclear type 2 Ab [Titer] in Cerebral spinal fluid

Hu2 Ab Titr CSF

Definition

Antineuronal Nuclear Antibody (ANNA) Type 2 Cerebrospinal Fluid (CSF) Titer. This antibody recognizes a set of protein antigens of 55 and 80 kD found in neuronal cell nuclei. Patients usually present with signs of midbrain, brain stem, cerebellar and/or spinal cord dysfunction. Ocular opsoclonus-myoclonus may be a symptom. Para neoplastic opsoclonus, which is characterized by involuntary rapid movement of the eyes in both vertical and horizontal planes, is most often associated with breast cancer and SCLC (small lung cell carcinoma). The autoantibody has also been detected in patients with bladder and cervical cancer. Paraneoplastic syndromes are autoantibody-mediated neurologic disorders associated with underlying tumors. These syndromes arise when systemic tumors express antigens normally found only in neural tissues. Information from http://www.clinlabnavigator.com accessed 2008 14 02.

ABS; Aby; ANNA 2; ANNA-2; Antby; Anti; Antibodies; Antibody; Autoantibodies; Autoantibody; Cerebral spinal fluid; Cerebrospinal Fl; Dilution factor; Dilution Factor (Titer); Hu; Hu2; II; Neuro; Neurology; Neuronal nuclear type II; Nuc; Paraneoplastic syndrome; Point in time; Random; RI; Serology; SmQn; Spinal Fl; Spinal Fld; Spinal Flu; Spinal Fluid; Titer; Titered; Titre; Ttr