Glial nuclear type 1 Ab [Titer] in Cerebral spinal fluid

Glial nuc type 1 Ab Titr CSF

Definition

Glial Nuclear Antibody Antibody (AGNA) Type 1 Cerebrospinal Fluid (CSF) Titer. This antibody is a marker found in paraneoplastic syndrome associated with small cell lung carcinoma (SCLC). It is also closely associated with paraneoplastic Lambert-Easton Myasthenia Syndrome (LEMS). There appears to be a tight association between AGNA and voltage-gated calcium channel antibodies in patients with SCLC. Patients with AGNA have characteristic nuclear staining of the Bergmann glia in the Purkinje cell layer of the cerebellum. Information from "Paraneoplastic Limbic encephalitis associated with potassium channel antibodies: value of anti-glial nuclear antibodies in identifying the tumour" by L. Zuliani, A. Saiz, B. Tavolato, B. Giometto, A. Vincent and Francesc Graus, JNNP m 2007; 78; p. 204-205.

ABS; Aby; AGNA; AGNA-1; Antby; Anti; Antibodies; Antibody; Autoantibodies; Autoantibody; Cerebral spinal fluid; Cerebrospinal Fl; Dilution factor; Dilution Factor (Titer); Glial nuc type 1; i; Lambert-Eaton myasthenic syndrome; Nuc; Paraneoplastic Antibody; Paraneoplastic syndrome; Point in time; Random; Serology; SmQn; Sox1; Sox1 nuclear antigen; Spinal Fl; Spinal Fld; Spinal Flu; Spinal Fluid; Titer; Titered; Titre; Ttr