53758-9

LOINC 2.82

HLA-DRB1 SBT [Type] in Specimen by High resolution

HLA-DRB1 SBT Spec High Res

Definition

  • HLA-DRB typing identifies HLA allelic polymorphism using DNA amplified by Polymerase Chain Reaction(PCR). HLA typing is vital for bone marrow transplantation. Well-matched donors increase patient survival and decreases incidence of graft vs.host disease. HLA-DRB1 sequence typing is used to identify unrelated allogeneic bone marrow donors who are HLA-DRB genotypic matches to the recipient. For DRB1, the allelic variability is mainly in the second exon, clustered in three distinct regions that show variance. If fewer than two alleles is reported for a locus, the patient is likely to be homozygous for that locus, but the possibility of the presence of rare alleles exists. Information from ARUP Laboratories 2007 07 17.

Component

  • HLA-DRB1 SBT

Specimen / system

  • XXX

Class

  • HLA

Property

  • Type

Scale

  • Nom

Method

  • High resolution

Related names

  • Genetics; Heredity; Heritable; HLA ANTIGEN; Human Leukocyte Antigen; Inherited; Misc; Miscellaneous; Nominal; Other; Point in time; Random; Sequence based typing; Spec; To be specified in another part of the message; Typ; Unspecified

Index terms

  • Genetics
  • Heredity
  • Heritable
  • HLA ANTIGEN
  • Human Leukocyte Antigen
  • Inherited
  • Misc
  • Miscellaneous
  • Nominal
  • Other
  • Point in time
  • Random
  • Sequence based typing
  • Spec
  • To be specified in another part of the message
  • Typ
  • Unspecified