HLA-A+B+C SBT [Interpretation] by High resolution

HLA-A+B+C SBT High Res-Imp

Definition

HLA-ABC sequence based typing results in HLA allele assignment for each HLA locus(A,B,C). HLA antigens are the major histocompatibility antigens. HLA Class 1 Sequence-Based typing (HLA-SBT) is used to identify HLA allelic polymorphisms at the level of individual nucleotides using genomic DNA amplified by polymerase chain reaction(PCR). If fewer than two alleles are reported for a locus, the patient can most likely be considered homozygous for that locus, but there is a possibility of an undetected rare allele. HLA-SBT should be used in addition to HLA Class 1 serology and/or low to intermediate resolution molecular typing using either SSP(sequence-specific primers) or SSOPH(sequence-specific oligonucleotide blot hydridization) technology. For clinical purposes, this test should be used as a reflex test to identify unrelated bone marrow donors who are HLA A,B, and C genotypic matches with the intended recipient.

A,B; Blood; Genetics; Heredity; Heritable; HLA ANTIGEN; HLA class I; Human Leukocyte Antigen; Impression; Impression/interpretation of study; Impressions; Inherited; Interp; Interpretation; Nominal; Point in time; Random; Sequence based typing; Tissue; Tissue, unspecified; WB; Whole blood; Whole blood or Tissue