T-cell receptor excision circle [#/volume] in DBS by NAA with probe detection

TREC # DBS NAA+probe

Definition

In newborn screening laboratories where dried blood spots (DBS) are the only available specimens, the test for T cell receptor excision circles (TREC) has been established as a reliable method in population-based pilot studies. TRECs are circular episomal DNA generated at the rearrangement of T cell antigen-receptor gene segments during maturation of T lymphocytes in the thymus. They are non-replicating byproducts that stay in the recent thymic emigrants in the peripheral blood. As such, they can serve as sensitive markers of T cell production in the newborn infant.

#; 3 Self-Sustaining Sequence Replication; 3SR SR; ABS; absolute; absolutes; Amplif; Amplification; Amplified; Blood; Chemistry; Cnt; Count; Count/volume; CT; DBS; DNA NUCLEIC ACID PROBE; DNA probe; Dried blood spot; Filter paper; FP; LAT; LCR; Ligase chain reaction; Ligation-activated transcription; NAA+probe; NAAT; NASBA; Nucleic acid sequence based analysis; Number concentration; Number Concentration (count/vol); PCR; Point in time; Polymerase chain reaction; Probe amp; Probe with ampification; Probe with target amplification; QBR; QNT; Quan; Quant; Quantitative; Random; Rec; Recept; Receptors; Recp; Recptr; SDA; Strand Displacement Amplification; T cell; T prime; TMA; Transcription mediated amplification; TREC; UCHL-1; Viral load; WB; Whole blood

19 further terms