PhenX - fasting C-peptide assay for residual beta cell function protocol 141201

Fasting C-peptide proto

Definition

This protocol provides instructions for drawing, processing and storing blood according to the National Health and Nutrition Examination Survey (NHANES) methods. As there are no standard assays for C-peptide, the protocol also provides basic guidelines to aid comparability among different studies. Although all three are valuable stand alone measures and all should be collected if resources are available, the Diabetes Working Group recommends that investigators prioritize Insulin 1st, C-peptide 2nd and Proinsulin 3rd. This is because results from the Insulin bioassay can be combined with results from Fasting Plasma Glucose bioassay to derive the homeostatic model assessment (HOMA) of insulin resistance and pancreatic beta cell function. The Diabetes Working Group notes that while it is not the preferred method, the C-peptide Assay can be performed on individuals who have not met the fasting requirements.

B; C peptide; Connecting peptide of insulin; Fasting C-peptide proto; FCN; Func; Funct; Pan; Panel; PANEL.PHENX; Panl; Pept; Pnl; Point in time; Pro-insulin c peptide; Random