Skin IgG Ab [Presence] in Serum by Guinea pig esophagus substrate

Skin IgG Ser Ql GP esoph

Definition

The detection of skin antibodies assists in the diagnosis of chronic vesicular-bullous diseases such as pemphigus and pemphigoid. When patient sera are incubated on monkey or guinea pig esophagus sections, anti-skin antibodies present in the serum will bind with disease-specific patterns by immunofluorescence. For example, the intercellular (IC) antibody pattern diagnoses pemphigus with a 90% sensitivity. Testing with the 2 different species of esophagus sections (monkey and guinea pig) assists in distinguishing different forms of pemphigus. Antibodies following a basement membrane pattern are present in bullous pemphigoid (70%), vesicular pemphigoid (50%) and cicatricial pemphigoid (10%).

ABS; Aby; Antby; Anti; Antibodies; Antibody; Autoantibodies; Autoantibody; GP esoph; GPE; Immune globulin G; Immunoglobulin G; Integument; Ordinal; Point in time; PR; QL; Qual; Qualitative; Random; Screen; Serology; Serum; SR