Skin IgG Ab [Titer] in Serum by Monkey esophagus substrate

Skin IgG Titr Ser Monkey esoph

Definition

The detection of skin antibodies assists in the diagnosis of chronic vesicular-bullous diseases such as pemphigus and pemphigoid. When patient sera are incubated on monkey or guinea pig esophagus sections, anti-skin antibodies present in the serum will bind with disease-specific patterns by immunofluorescence. For example, the intercellular (IC) antibody pattern diagnoses pemphigus with a 90% sensitivity. Testing with the 2 different species of esophagus sections (monkey and guinea pig) assists in distinguishing different forms of pemphigus. Antibodies following a basement membrane pattern are present in bullous pemphigoid (70%), vesicular pemphigoid (50%) and cicatricial pemphigoid (10%).

ABS; Aby; Antby; Anti; Antibodies; Antibody; Autoantibodies; Autoantibody; Dilution factor; Dilution Factor (Titer); Immune globulin G; Immunoglobulin G; Integument; Point in time; Random; Serology; Serum; SmQn; SR; Titer; Titered; Titre; Ttr