Epstein-Barr virus-encoded RNA 1 [Presence] in Tissue by Probe

EBV-encoded RNA1 Tiss Ql Probe

Definition

This term is used for the detection of nuclear Epstein-Barr virus-encoded RNA 1 (EBER1) by in situ hybridization on tissue. Presence of EBER1 indicates a latent EBV infection. EBV encodes two small nuclear RNAs, EBER1 and EBER2, which are the most abundant viral transcripts in latently infected cells. They are non-polyadenylated and thus not translated into protein. Their function is to inhibit interferon-mediated antiviral effects and apoptosis. Since they are expressed at high levels (around a million copies per latently infected cell), they are considered to be an ideal marker of latent EBV infection. In situ hybridization targeting one or both EBERs is used to determine whether a biopsied tumor is EBV-related.

DNA NUCLEIC ACID PROBE; DNA probe; EBER; EBER1; EBV; EBV-encoded RNA1; Epstein-Barr virus; Epstn; HHV-4; human herpesvirus 4; i; ID; Infectious Disease; InfectiousDisease; Microbiology; Mono; Mononucleosis; Ordinal; Point in time; PR; QL; Qual; Qualitative; Random; Ribonucleic acid; Screen; Tissue; Tissue, unspecified