Multiple inhalant allergen IgE Ab [Presence] in Serum by Immunoassay

MIA IgE Ql IA

Definition

This term was created for (but not limited to) Siemen's Immulite 2000 AlaTOP allergy screen, a chemiluminescent enzyme-labeled sequential immunoassay used to qualitatively detect IgE antibodies specific to inhalant allergens in serum. The AlaTOP constituents usually include the following 12 allergens: Dermatophagoides pteronyssinus (dust mite), cat epithelium, dog dander, Cynodon dactylon (Bermuda grass), Phleum pretense (timothy grass), Penicillium notatum, Alternaria tenuis, Ambrosia artemisiifolia (common ragweed), Plantago lanceolata (English plantain), Parietaria officinalis (wall pelitory), Betula papyrifera (paper birch), and Cryptomeria japonica (Japanese cedar) (Source: http://www.cdc.gov/niosh/hhe/reports/pdfs/2005-0248-3077.pdf) The Phadiatop assay has a fixed set of allergens that is not stated by the manufacturer (http://www.jiaci.org/issues/vol15issue02/7.pdf), but probably contains a similar subset of components. Test results are determined by the calculation of a signal to cutoff (S/CO) ratio, which is calculated automatically by the instrument. The results are reported as indeterminate (ratio between 0.9 and <1.1), reactive (ratio of >=1.1) and nonreactive (ratio of < 0.9).

ABS; Aby; AlaTOP; Allergen; Allergens; ALLERGY TESTING; Alrgen; Antby; Anti; Antibodies; Antibody; Autoantibodies; Autoantibody; EIA; ELFA; ELISA; Enzyme immunoassay; IAA; Immune globulin E; Immunoglobulin E; MEIA; MIA; Mult; Multi; Ordinal; Phadiatop; Point in time; PR; QL; Qual; Qualitative; Random; Screen; Serum; SR; SUDS