70278-7

LOINC 2.82

t(3;21)(q26;q22.3)(MECOM,RUNX1) fusion transcript [Presence] in Blood or Tissue by Molecular genetics method

t(3;21)(MECOM,RUNX1) Bld/T Ql

Definition

  • This term is used to identify a leukemia causing chromosomal translocation resulting in a gene fusion between MECOM (3q26) and RUNX1 (21q22) genes. The term was created for (but not limited to) DNA Technology's HemaVision HV01-28N kit, a qualitative in vitro diagnostic test for 28 leukemia causing chromosomal alterations including more than 80 breakpoints plus associated mRNA splice variants. Reverse transcription followed by multiplex nested polymerase chain reactions (RT-PCR) and agarose gel electrophoresis are used to identify gene fusions caused by chromosomal translocations, gene deletions or inversions. Testing information is useful for predicting development of the disease and selection of treatment.

Component

  • t(3;21)(q26;q22.3)(MECOM,RUNX1) fusion transcript

Specimen / system

  • Bld/Tiss

Class

  • MOLPATH.TRNLOC

Property

  • Arb

Scale

  • Ord

Method

  • Molgen

Related names

  • 21q22.3; Acute myeloid leukemia 1; AML1; Arbitrary; Blood; CBFA2; DNA; gene fusion; gene translocation; Genetics; Heredity; Heritable; III; Inherited; Molecular genetics; Molecular pathology; MOLPATH; MOLPATH.TRANSLOCATION; Ordinal; PCR; Point in time; QL; Qual; Qualitative; Random; RNA; Screen; T prime; t(3;21)(MECOM,RUNX1); Tissue; Tissue, unspecified; translocation; WB; Whole blood; Whole blood or Tissue

Index terms

  • 21)(MECOM,RUNX1)
  • 21q22.3
  • Acute myeloid leukemia 1
  • AML1
  • Arbitrary
  • Blood
  • CBFA2
  • DNA
  • gene fusion
  • gene translocation
  • Genetics
  • Heredity
  • Heritable
  • III
  • Inherited
  • Molecular genetics
  • Molecular pathology
  • MOLPATH
  • MOLPATH.TRANSLOCATION
  • Ordinal
  • PCR
  • Point in time
  • QL
  • Qual
  • Qualitative
  • Random
  • RNA
  • Screen
  • T prime
  • t(3
  • Tissue
  • Tissue, unspecified
  • translocation
  • WB
  • Whole blood
  • Whole blood or Tissue