t(5;17)(q25.1;q21.1)(NPM1,RARA) fusion transcript [Presence] in Blood or Tissue by Molecular genetics method

t(5;17)(NPM1,RARA) Bld/T Ql

Definition

This term is used to identify a leukemia causing chromosomal translocation resulting in a gene fusion between NPM1 (5q34) and RARA (17q21) genes. The term was created for (but not limited to) DNA Technology's HemaVision HV01-28N kit, a qualitative in vitro diagnostic test for 28 leukemia causing chromosomal alterations including more than 80 breakpoints plus associated mRNA splice variants. Reverse transcription followed by multiplex nested polymerase chain reactions (RT-PCR) and agarose gel electrophoresis are used to identify gene fusions caused by chromosomal translocations, gene deletions or inversions. Testing information is useful for predicting development of the disease and selection of treatment.

Arbitrary; Blood; DNA; gene fusion; gene translocation; Genetics; Heredity; Heritable; Inherited; Molecular genetics; Molecular pathology; MOLPATH; MOLPATH.TRANSLOCATION; NPM; NR1B1; Nucleolar phosphoprotein b23; Numatrin; Ordinal; PCR; Point in time; QL; Qual; Qualitative; Random; RAR alpha form; RARalpha; Retinoic acid receptor alpha; RNA; Screen; T prime; t(5;17)(NPM1,RARA); Tissue; Tissue, unspecified; translocation; WB; Whole blood; Whole blood or Tissue