Cortisol Free/Cortisone free [Molar ratio] in Urine

Cortis F/Cortisone Free Ur-sRto

Definition

Determining the ratio of urinary-free cortisol to cortisone is useful in evaluating patients with apparent mineralocorticoid excess (AME) syndrome and other forms of adrenal insufficiency. Higher ratios (> 0.5) are observed in patients with AME syndrome and indicate insufficient levels of 11-beta-hydroxy steroid dehydrogenase type 2 (11-beta HSD2), which converts cortisol to cortisone. Lower ratios (<0.15) suggests low activity of the 11-beta-HSD1 enzyme, which converts cortisone to cortisol, and may explain reduced effectiveness of cortisone treatment.

11-beta HSD; 11-beta-HSD1; 11-beta-HSD2; 11-beta-hydroxy steroid dehydrogenase; 11-ß-HSD1; 11-ß-HSD2; 17-Hydroxycorticosterone; c155; Chemistry; Compound E; Compound F; Coritsol; Cort; Cortis F; Cortisone free; F; FR; hydrocortisone; Non-protein bound; Point in time; QNT; Quan; Quant; Quantitative; Random; Scrto; Substance concentration ratio; Substance ratio; UA; UR; Urn