t(8;21)(q22;q22.3)(RUNX1T1,RUNX1) fusion transcript/control transcript [# Ratio] in Blood or Tissue by Molecular genetics method

t(8;21)(RUNX1T1,RUNX1)/control Bld/T

Definition

Translocations between chromosomes 8 and 21, resulting in a fused transcript between RUNXT1 (8q22) and RUNX1 (21q22.3), can be detected with real-time PCR. An endogenous control gene transcript (e.g. ABL1, GUS or BCR) is amplified along with the fusion transcript of interest. Standard curves of known amounts of both the control and fusion transcript are used to calculate the ratio of the fusion transcript signal to the control gene signal.

21q22.3; ABL; ABL1; ABL1 transcript; Acute myelogenous leukemia 1 translocation 1, cyclin-D related; Acute myeloid leukemia; Acute myeloid leukemia 1; AML; AML1; AML1T1L myeloid translocation gene on 8q22; Blood; CBFA2; CBFA2T1; CDR; control gene; Core binding factor runt domain alpha subunit 2; DNA; ETO; gene fusion; gene translocation; Genetics; Heredity; Heritable; Inherited; MGC2796; Molecular genetics; Molecular pathology; MOLPATH; MOLPATH.TRANSLOCATION; MTG8; Number ratio; PCR; Point in time; QNT; Quan; Quant; Quantitative; Random; RNA; T prime; t(8,21)(RUNX1T1,RUNX1) gene translocation; t(8;21)(RUNX1T1,RUNX1); Tissue; Tissue, unspecified; translocation; WB; Whole blood; Whole blood or Tissue; ZMYND2

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