t(8;21)(q22;q22.3)(RUNX1T1,RUNX1) fusion transcript/control transcript [# Ratio] in Bone marrow by Molecular genetics method

t(8;21)(RUNX1T1,RUNX1)/control Mar

Definition

Translocations between chromosomes 8 and 21, resulting in a fused transcript between RUNXT1 (8q22) and RUNX1 (21q22.3), can be detected with real-time PCR. An endogenous control gene transcript (e.g. ABL1, GUS or BCR) is amplified along with the fusion transcript of interest. Standard curves of known amounts of both the control and fusion transcript are used to calculate the ratio of the fusion transcript signal to the control gene signal.

21q22.3; ABL; ABL1; ABL1 transcript; Acute myelogenous leukemia 1 translocation 1, cyclin-D related; Acute myeloid leukemia; Acute myeloid leukemia 1; AML; AML1; AML1T1L myeloid translocation gene on 8q22; BM; BON; Bone marrow; CBFA2; CBFA2T1; CDR; control gene; Core binding factor runt domain alpha subunit 2; DNA; ETO; gene fusion; gene translocation; Genetics; Heredity; Heritable; Inherited; MAR; Marrow (bone); MGC2796; minimal angle of resolution; Minimum angle of resolution; Molecular genetics; Molecular pathology; MOLPATH; MOLPATH.TRANSLOCATION; MTG8; Number ratio; PCR; Point in time; QNT; Quan; Quant; Quantitative; Random; RNA; T prime; t(8,21)(RUNX1T1,RUNX1) gene translocation; t(8;21)(RUNX1T1,RUNX1); translocation; ZMYND2

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