72209-0LOINC 2.82
inv(16)(p13.1;q22.1)(MYH11,CBFB) fusion transcript/control transcript [# Ratio] in Bone marrow by Molecular genetics method
inv(16)(p13;q22)/control Mar
Definition
- A pericentric inversion of chromosome 16, inv(16)(p13;q22), results in a fused transcript between MYH11 (16p13.1) and CBFB (16q22.1) genes and is known to cause acute myeloid leukemia (AML). Techniques like real-time PCR are used to detect the MYH11-CBFB fused transcript. An endogenous control gene transcript (e.g. ABL1, GUS or BCR) is amplified along with the fusion transcript of interest. Standard curves of known amounts of both the control and fusion transcript are used to calculate the ratio of the fusion transcript signal to the control gene signal.
Component
- inv(16)(p13.1;q22.1)(MYH11,CBFB) fusion transcript/control transcript
Specimen / system
- Bone mar
Class
- MOLPATH.INV
Property
- NRto
Scale
- Qn
Method
- Molgen
Related names
- ABL; ABL1; ABL1 transcript; Acute myeloid leukemia; AML; BM; BON; Bone marrow; control gene; DNA; gene fusion; gene translocation; inv(16)(CBFB,MYH11) gene inversion; inv(16)(p13;q22); Inversion 16; MAR; Marrow (bone); minimal angle of resolution; Minimum angle of resolution; Molecular genetics; Molecular pathology; MOLPATH; MOLPATH.INV; Number ratio; PCR; Point in time; QNT; Quan; Quant; Quantitative; Random; RNA; translocation
Index terms
- ABL
- ABL1
- ABL1 transcript
- Acute myeloid leukemia
- AML
- BM
- BON
- Bone marrow
- control gene
- DNA
- gene fusion
- gene translocation
- inv(16)(CBFB,MYH11) gene inversion
- inv(16)(p13
- Inversion 16
- MAR
- Marrow (bone)
- minimal angle of resolution
- Minimum angle of resolution
- Molecular genetics
- Molecular pathology
- MOLPATH
- MOLPATH.INV
- Number ratio
- PCR
- Point in time
- q22)
- QNT
- Quan
- Quant
- Quantitative
- Random
- RNA
- translocation