t(1;19)(q23.3;p13.3)(PBX1,TCF3) fusion transcript/control transcript [# Ratio] in Blood or Tissue by Molecular genetics method

t(1;19)(PBX1,TCF3)/control Bld/T

Definition

A translocation involving chromosomes 1 and 19, t(1;19)(q23;p13), results in a fused transcript between TCF3 (formerly E2A) and PBX1 (formerly prl) genes. The TCF3-PBX1 fusion gene is found in approximately 3% of childhood and adult precursor-B acute lymphoblastic leukemia (ALL). This code is based on, but not limited to, Ispogen's E2A-PBX1 FusionQuant® kit, which uses real-time Quantitative RQ-PCR to quantify the expression level of specific TCF3(E2A)-PBX1 fusion gene transcripts relative to a control gene transcript (e.g. ABL1). From the manufacturer's website (2012), "Quantification of E2A-PBX1 fusion gene transcripts has been standardized in the EAC (Europe Against Cancer) program [Gabert J et al. Leukemia. 2003, Beillard E et al. Leukemia. 2003], and IPSOGEN FusionQuant® kits use this validated technology to calibrate and normalize RQ-PCR results."

ABL; ABL1; ABL1 transcript; Acute lymphoblastic leukaemia; Acute lymphoblastic leukemia; Acute myeloid leukemia; ALL; AML; Blood; control gene; DNA; E2A Immunoglobulin enhancer binding factors E12/E47; gene fusion; gene translocation; Genetics; Heredity; Heritable; i; Immunoglobulin transcription factor 1; Inherited; ITF1; Molecular genetics; Molecular pathology; MOLPATH; MOLPATH.TRANSLOCATION; Non-Hodgkin lymphoma; Number ratio; PBXP1; PCR; Point in time; Pre-B cell leukemia transcription factor-1; QNT; Quan; Quant; Quantitative; Random; RNA; T prime; t(1;19)(PBX1,TCF3); Tissue; Tissue, unspecified; Transcription factor 3; translocation; WB; Whole blood; Whole blood or Tissue

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