FLT3 gene.p.Asp835+Ile836 mutations [Presence] in Blood or Tissue by Molecular genetics method

FLT3 p.D835+I836 Bld/T Ql

Definition

Point mutations and deletions of codons D835 and I836 within the second tyrosine kinase domain (protein activation loop) of the FLT3 gene are detected by molecular genetic methods (e.g. PCR-based assays). This code was created for, but not limited to Invivoscribe's LeukoStrat(tm) FLT3 Gel Detection Mutation Assay, which detects the presence or absence of either D835 or I836 mutations within the second TKD but does not identify specific TKD mutations. FLT3-TKD mutations occur in approximately 7% of patients with acute myelogenous leukemia (AML).

Acute myeloid leukemia; AML; Blood; CD135; FL cytokine receptor precursor; FLK2; FLK-2; FLT3 p.D835; FLT3 p.D835+I836; FLT3 TKD; FLT3 tyrosine kinase domain; fms-like tyrosine kinase 3; fms-related tyrosine kinase 3; Genetics; Heredity; Heritable; Inherited; Molecular genetics; Molecular pathology; MOLPATH; MOLPATH.MUTATIONS; Mut; Mutation; Muts; Ordinal; P prime; PCR; Point in time; PR; QL; Qual; Qualitative; Random; Screen; Stem cell tyrosine kinase 1; STK1; STK-1; Tissue; Tissue, unspecified; WB; Whole blood; Whole blood or Tissue

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