CYP2D6 gene and CYP2C19 gene targeted mutation analysis panel - Blood or Tissue by Molecular genetics method

CYP2D6+CYP2C19 pnl Bld/T

Definition

CYP2D6 and CYP2C19 cytochrome P450 genes play a major role in the metabolism of many widely prescribed drugs, including anti-depressants, anti-psychotics, anti-epileptics, proton pump inhibitors, and beta-blockers. The CYP2D6 gene has at least 70 allelic variants resulting in four phenotypic types: poor metabolizers with gene inactivation of both alleles, intermediate metabolizers with one reduced activity allele and one null allele, extensive metabolizers with at least one functional allele, and ultra-rapid metabolizers with excess enzymatic activity due to multiple copies of functional alleles from gene duplication. The CYP2C19 gene has two major variant alleles that result in enzyme deficiency. This panel term is created for, but not limited to, Roche Diagnostics' AmpliChip CYP450 assay, which detects 29 polymorphisms in the 2D6 and 2 polymorphisms in the 2C19 gene, as well as gene duplications and deletions.

Blood; CPCJ; CPD6; CYP2C; CYP2D; CYP2D@; CYP2D6+CYP2C19; CYP2D6+CYP2C19 pnl; CYP2D7AP; CYP2D7BP; CYP2D7P2; CYP2D8P2; CYP2DL1; CYPIIC17; CYPIIC19; CYPIID6; Cytochrome p450; cytochrome P-450 II C; cytochrome P450, family 2, subfamily C, polypeptide 19; cytochrome P450, family 2, subfamily D, polypeptide 6; Debrisoquine hydroxylation gene; HGNC:2629; Molecular genetics; Molecular pathology; MOLPATH; MOLPATH.PHARMG; Mut; Mutations; P450C2C; P450C2D; P450DB1; P450-DB1; P450IIC19; Pan; Panel.molpath; Panel.molpath.pharmg; Panl; PCR; Pnl; Point in time; Random; Tissue; Tissue, unspecified; WB; Whole blood; Whole blood or Tissue

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