Mycobacterium tuberculosis stimulated gamma interferon ESAT-6 Ag spot count [#] in Blood

M TB IFN-g.ESAT-6 Ag Bld

Definition

The count of spots (0 to >20) in a patient's T cells that represent IFN-γ released in response to the presence of M. tuberculosis early secretory antigenic target-6 (ESAT-6) antigens. The spot count provides a measurement of the abundance of Mycobacterium tuberculosis sensitive effector T cells in the peripheral blood. This term is based on, but not limited in use to, Oxford Immunotec's T-SPOT.TB assay, used to diagnose M. tuberculosis. T-SPOT.TB assay uses enzyme-linked immunospot (ELISPOT) methodology to enumerate M. tuberculosis-sensitized T cells by capturing interferon-gamma (IFN-y) in the vicinity of T cells in the patient's whole blood. In the T-SPOT.TB assay, the test result is positive if [ESAT-6 (Panel A) - negative control spots] and/or [CFP10 (Panel B) - negative control spots] is greater than or equal to 8 spots. The test result is negative if both [Panel A - negative control] and/or [Panel B - negative control] is less than or equal to 4 spots.

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