Fetal blood [Volume] in Blood by Flow cytometry (FC)

Fetal blood Vol Bld FC

Definition

Measures the volume of fetal blood in the maternal circulation as calculated from the flow cytometry fetal cell count. Fetal maternal hemorrhage (FMH) is the transfer of fetal blood to the maternal circulation. For Rh negative mothers this may cause anti-D sensitization that can result in hemolytic disease of the newborn (HDN) in subsequent pregnancies. Anti-D immunoglobulin can be given to prevent sensitization. Quantification of the volume of FMH can aid in the calculation of the dose of anti-D immunoglobulin needed to prevent sensitization. Flow cytometry can measure presence of fetal red cells in the mother's blood sample using either fetal hemoglobin (HbF) or D positive antigens on the fetal cells. Glycophorin A (CD235a) may also be included in the method.

Blood; Dynamic; FC; Fetomaternal hemorrhage; FMH; HEMATOLOGY/CELL COUNTS; Point in time; QNT; Quan; Quant; Quantitative; Random; Volume; WB; Whole blood