Human papilloma virus 18+45 E6+E7 mRNA [Presence] in Cervix by NAA with probe detection

HPV18+45 E6+E7 mRNA Cvx Ql NAA+probe

Definition

Detects E6/E7 viral messenger RNA (mRNA) of human papillomavirus (HPV) types 18 and 45 in cervical specimens from women with positive HPV assay results. E6/E7 oncogenes must be expressed for malignant transformation. For women 21-years and older with atypical squamous cells of undetermined significance (ASC-US) cervical cytology results, and HPV positive assay results, this assay can be used to assess the presence or absence of high-risk HPV genotypes 18, and/or 45. For women 30-years and older, the HPV 18, and/or 45 genotype assay can be used to test samples from women with HPV assay positive results, along with cervical cytology results. This assay has not been evaluated for HPV vaccinated patients or in cases of suspected abuse. It does not differentiate HPV 18 and HPV 45. This term was created for, but not limited in use to, the Aptima HPV 16 18/45 genotype assay which uses target capture, target amplification by transcription-mediated amplification and detection of the amplification products by hybridization protection. To report results for HPV 16 see Human papilloma virus 16 E6+E7 mRNA [Presence] in Cervix by Probe and signal amplification method [LOINC: 82456-5].

3 Self-Sustaining Sequence Replication; 3SR SR; Amplif; Amplification; Amplified; Cervix; DNA NUCLEIC ACID PROBE; DNA probe; Genital tract; Genital warts; Gyn; Gynecology; HPV; HPV 18; HPV 45; HPV18; HPV18+45 E6+E7 mRNA; Human papilloma virus; Human papillomavirus; ID; Infectious Disease; InfectiousDisease; LAT; LCR; Ligase chain reaction; Ligation-activated transcription; Microbiology; NAA+probe; NAAT; NASBA; Nucleic acid sequence based analysis; OB; ObGyn; Obstetrics; Ordinal; Papilloma virus high risk; PCR; Point in time; Polymerase chain reaction; PR; Probe amp; Probe with ampification; Probe with target amplification; QBR; QL; Qual; Qualitative; Random; Screen; SDA; Strand Displacement Amplification; TMA; Transcription mediated amplification

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